Rapamune (Sirolimus)

Take Rapamune exactly as prescribed by your doctor, without changing the dose or stopping it without medical advice. It can be taken with or without food, but it is important to be consistent each time.

The medication should be taken at the same time each day, and if you are also taking cyclosporine, Rapamune should be taken four hours after your cyclosporine dose.

For those using the tablet form, swallow it whole without crushing, chewing, or splitting. Avoid grapefruit and grapefruit juice, as they can increase Rapamune levels in the blood and lead to potential side effects.

Regular blood tests will be required to monitor drug levels and ensure safe and effective treatment. Always follow your doctor’s instructions carefully and report any unusual symptoms or side effects promptly.

The list provided below includes drugs that are recognized to interact with Rapamune. However, it is important to note that this is not an exhaustive compilation of all potential drug interactions.

• Prednisone
• Amlodipine
• Pravastatin
• Atorvastatin
• Acyclovir
• Crestor (Rosuvastatin)
• Lipitor (Atorvastatin)
• Lisinopril
• Metformin
• Myfortic (Mycophenolic Acid)
• Cellcept (Mycophenolate Mofetil)

To stay safe and avoid problems, inform your doctor about all the medications you are currently using. This includes both prescribed medications and over-the-counter products. They will assess the potential interaction and determine whether it is beneficial to use both drugs together. If not, adjustments need to be made to your treatment plan.

Some known side effects of Rapamune are listed below. Please note that this is not a complete list of all possible side effects of Rapamune.

• Nausea
• Changes in Blood Levels of Cholesterol
• Swelling in the Ankles, Feet, or Hands
• Increased Protein in Your Urine
• High Blood Pressure
• Diarrhea
• Belly Pain

If you encounter any indications or symptoms of severe side effects while taking this medication, it is important to consult your doctor or seek immediate medical attention.

Please inform your doctor about any side effects you experience. If you find these side effects difficult to manage, contact your doctor for medical advice.

The starting dose of Rapamune (sirolimus) depends on its use. For kidney transplant patients, the first dose is 6 mg once after the transplant, followed by a daily dose of 2 mg. The dose may change based on blood test results. For those switching from cyclosporine to Rapamune, cyclosporine is slowly reduced over 4-8 weeks, and the Rapamune dose is adjusted to keep blood levels between 12-20 ng/mL. It is important to follow your doctor’s instructions and get regular blood tests to ensure the right dose.

Starting price of Rapamune 1mg in Canada

- 100 tabs - $1,190.25 USD ($11.90 per tab)
- 200 tabs - $2,325.25 USD ($11.63 per tab)
- 300 tabs - $3,437.25 USD ($11.46 per tab)

Scroll up to see the specific pricing for each product, which is available in various strengths for both brand-name and generic options.