Vivelle Dot (Estradiol)

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What is Vivelle Dot (Estradiol) used for?

Vivelle Dot (Estradiol patch) is used to provide estrogen hormones for women experiencing menopause. This reduces the symptoms of menopause including vaginal dryness and hot flashes. It can also provide estrogen when the body does not produce enough naturally. This can be due to other medical conditions such as ovarian failure and hypogonadism. It can treat symptoms concerning the vagina or osteoporosis but other products tend to work better. It is a twice weekly patch that needs to be replaced every 3-4 days.

Vivelle Dot (Estradiol) Information

How does Estradot Patch work?

Estradot patches provide estrogen to the body when it cannot produce it on its own.

How do you use Estradot Patch?

The skin patches are applied on the lower back, hip, abdomen or buttocks twice a week. It should be changed every 3 or 4 days. If you experience irritation, you can try applying the sticky side to a different part of your body. Call your doctor or pharmacist if you have trouble finding a place that is comfortable.

Women who have not had a hysterectomy should take progestin to prevent side effects. Avoid putting patches on or near the breasts and apply the patch to a different area from week to week. Do not place the patch on the same location 2 weeks in a row.

When applying the patch, find an area of clean, dry unbroken skin that is unlikely to be exposed to the sun. Tight clothing may also cause it to come off.
Avoid using tools to open the packaging. If you cut or damage the patch will need to be discarded. Remove any extra layers or packaging.

Hold the patch in place with your fingers for at least 10 seconds. Keep pressure on the edges to ensure it remains affixed. If it happens to fall off while bathing or swimming, attempt to reapply it when your skin is dry.
If you cannot get it to stick properly. Replace it with a fresh patch. Only use one patch at a time. Using extra patches can increase your risk of experiencing side effects.

Keep discard patches away from children and animals. Fold it so that the patch sticks to itself. Gently remove any adhesive that sticks to your skin. Check with your doctor or pharmacist if you forget to change or use a patch.

Estradot Patch Precautions and Warnings?

All orders from Sunshine Pharmacy are delivered in the manufacturer's packaging and include a medicine information sheet. We ask that you carefully read this information sheet and call us if you have any questions or do not understand the document.

Let your doctor know if you have a history of the following conditions:

  • Breast cancer
  • Porphyria
  • Tumors (estrogen-dependent)
  • Cancer
  • Blood clots (eg, deep vein thrombosis, pulmonary embolism)
  • Heart or blood vessel disease
  • Protein C, protein S deficiency
  • Hypertension
  • Jaundice during pregnancy
  • Hypothyroidism
  • Stroke
  • Hypertriglyceridemia
  • Edema
  • Epilepsy
  • Kidney disease
  • Migraine headache
  • Abnormal or unusual vaginal bleeding
  • Hereditary angioedema
  • Hypocalcemia
  • Diabetes
  • Asthma
  • Dementia
  • Endometriosis
  • Liver tumors
  • Gallbladder disease
  • Obesity
  • Liver disease
  • Hypercalcemia
  • Systemic lupus erythematosus (SLE)
  • Heart attack

They may affect how Estradiol works or it may worsen these conditions. Avoid grapefruit juice and grapefruit adjacent products during treatment. It may affect how much of the medication your body absorbs.

Call your doctor if you develop a skin condition from using this product. It may be a sign of an allergic reaction. Your doctor should advise you if you have a risk of developing allergies or other health conditions.

What Drugs Interact with Estradot Patch?

There are potential known drug interactions associated with Estradot Patch. You should disclose all of your current vitamins, supplements, OTC drugs, herbal products and all current prescription medicines. Our pharmacists will provide therapeutic screening for all orders against this supplied list.

Call your doctor or seek immediate medical attention if you experience an allergic reaction or drug interaction.

  • Prednisone
  • Telaprevir
  • Pixantrone
  • Lorlatinib
  • Nelfinavir
  • Cloxacillin
  • Fosaprepitant
  • Fexinidazole
  • Tigecycline
  • Amifampridine
  • Sugammadex
  • Cefuroxime
  • Doxycycline
  • Bacampicillin
  • Phenobarbital
  • Lesinurad
  • Mycophenolic Acid
  • Nevirapine
  • Elvitegravir
  • Abametapir
  • Cefdinir
  • Guar Gum
  • Ritonavir
  • Aprepitant
  • Encorafenib
  • Mycophenolate Mofetil
  • Octreotide
  • Cefprozil
  • Mitotane
  • Ceritinib

What are the Side Effects of Estradot Patch?

We do not list all possible known side effects.You may experience a side effect that is not provided here. If you find that you are noticing severe side effects call your doctor or one of our pharmacists for counseling and medical advice.

Your doctor will normally balance the benefits of treatment  versus any possible  adverse reactions. Please call us and speak to the pharmacist if you have concerns about buying Estradot Patch online


  • mood or mental changes
  • clay-colored stools
  • chills
  • stomach cramps, discomfort, upset, pain, or swelling
  • backache
  • confusion
  • mental depression
  • diarrhea
  • Acid or sour stomach
  • pain, redness, or swelling in the arm, foot, or leg
  • unusual tiredness or weakness
  • fluid-filled skin blisters
  • sore on the skin of the breast that does not heal
  • inverted nipple
  • trouble recognizing objects
  • yellow eyes or skin
  • increased in sexual ability, desire, drive, or performance
  • muscle spasm or jerking of all extremities
  • difficulty with swallowing
  • unexpected or excess milk flow from the breasts
  • heartburn
  • seizures
  • noisy breathing
  • blurred vision
  • hives, itching, skin rash
  • indigestion
  • increased hair growth, especially on the face
  • anxiety
  • leg cramps

Is there a generic Estradot Patch?

The generic product is the Estradiol patch.

Vivelle Dot (Estradiol) FAQs

Can estradiol patches be cut in half?

The information provided by the manufacturer indicates that it should never be altered or cut. It may affect how the patches work.

Can I put my estradiol patch on my arm?

It may be placed on the upper buttock or lower stomach. It must be placed on clean dry skin free of lotions or powders.

How do I keep my estradiol patch on?

Apply the patch firmly by holding it in place for 10 seconds. This will ensure that the patch stays on. Avoid putting it on damaged, irritated or oily skin. For best results, place it somewhere where it is unlikely to be disturbed.

How long for estradiol patch to start working?

On average, individuals report an improvement in 1-2 weeks.

What is the lowest dose of estradiol patch available?

The lowest dose available is 25mcg. Your doctor will advise you which strength works best to manage your symptoms.

Disclaimer: The information provided here is intended as supplementary information to that provided by your doctor. The guidance provided by your doctor supersedes any information provided on the website. Do not avoid or disregard any counseling from your licensed medical professional based on this information. If you have any medical questions that are not answered here, we do offer counseling from a pharmacist.