Arthrotec (Diclofenac/Misoprostol)

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What is Arthrotec (Diclofenac/Misoprostol) used for?

Rheumatoid arthritis pain, swelling, and joint stiffness can be reduced with Arthrotec (Diclofenac sodium/Misoprostol). The drug is classified as an NSAID (nonsteroidal anti-inflammatory drug). When taken with diclofenac, misoprostol protects the stomach from the irritating effects of the drug. This drug is recommended for individuals with a high risk of developing stomach/intestinal ulcers. Consider non-drug treatments for chronic conditions such as arthritis, as well as using other medications to relieve your pain. Please see the Warning section as well.

Arthrotec (Diclofenac/Misoprostol) FAQs

How To Use Arthrotec (Diclofenac/Misoprostol)?

Arthrotec should be taken as directed by your doctor. Follow all directions on the prescription label and read the medication guide provided with the medication. To treat your condition, use the lowest effective dose.

The stomach upset from Arthrotec can be reduced by taking it with food. Make sure you swallow the tablet whole without crushing, chewing, or breaking it.

This medicine should not be shared with anyone else, even if they have the same symptoms as you.

A doctor may need to perform frequent medical tests if you use Arthrotec long-term.
Moisture and heat should be kept away from the storage area.

What are the possible side effects of Arthrotec (Diclofenac/Misoprostol)?

The most commonly reported side effects of Arthrotec (Diclofenac/Misoprostol) include:

  • swelling of the hands or feet
  • gas
  • mental/mood changes
  • difficult or painful swallowing
  • ringing in your ears
  • menstrual problems/irregular periods
  • drowsiness
  • signs of infection (e.g., fever, persistent sore throat)
  • nausea
  • bloating
  • dizziness
  • unusual tiredness
  • vision changes
  • fainting
  • headache
  • blurred vision
  • easy bruising or bleeding
  • unusual vaginal bleeding
  • unexplained stiff neck
  • sudden or unexplained weight gain
  • changes in the amount of urine
  • fast or pounding heartbeat

There are other side effects that may occur that are not listed on this page.

Talk to your doctor if you are at if you have the risk factors of high blood pressure, as this drug can cause fluid retention. This may cause a worsening of high blood pressure and can potentially lead to heart failure. It may not be safe to take for individuals with an coronary artery bypass graft.

Call your doctor or seek immediate medical attention if you experience adverse events such as skin reactions or trouble breathing. This may not be safe for pregnant nursing women as it could lead to birth defects. Talk to your doctor or pharmacist if you become pregnant during treatment.

What are Drug Interactions of Arthrotec (Diclofenac/Misoprostol)?

Few known Drug Interactions of Arthrotec (Diclofenac/Misoprostol) are listed below.

    • Lyrica (Pregabalin)
    • Levothyroxine


A complete list of Arthrotec (Diclofenac/Misoprostol) Drug Interactions is not available on this page. Consult your physician if you have any questions about this medicine's drug interactions.

How much is Arthrotec cost in Canada?

Starting price of Arthrotec 50 50 mg /200mcg cost in Canada
- 250 tabs - $347.00 USD ($1.39 per tabs)

Starting price of Arthrotec 75 75mg/200mcg cost in Canada
- 250 tabs - $380.00 USD ($1.52 per tabs)

How much is generic equivalent Diclofenac/Misoprostol cost in Canada?

Starting price of Diclofenac/Misoprostol 50mg/200mcg cost in Canada
- 250 tabs - $115.00 USD ($0.46 per tabs)

Starting price of Diclofenac/Misoprostol 75mg/200mcg cost in Canada
- 250 tabs - $152.00 USD ($0.61 per tabs)

Do you need a prescription for Arthrotec (Diclofenac/Misoprostol) in Canada?

You do require a prescription to order Arthrotec (Diclofenac/Misoprostol) in Canada. Licensed pharmacies are unable to dispense prescription required drugs without one.

Disclaimer: The information contained in this page is to provide basic information on this product and is not intended to substitute medical advice from a licensed doctor. Always make sure to consult with a doctor before ordering medication online from Canada. Do not avoid or delay seeing a healthcare provider based on what you read here.