What is Otezla (apremilast) used for?
In the treatment of Behçet's disease, plaque psoriasis, and active psoriatic arthritis. The tablets are used twice a day to lower inflammation. During its action, apremilast inhibits an enzyme within your immune system that stimulates inflammation in your body and affects certain cells. This medicine belongs to the group of PDE4 inhibitors (Phosphodiesterase-4 Inhibitors). These lower inflammation by increasing our bodies' own messenger, cAMP (cyclic adenosine monophosphate).Otezla (Apremilast) Information
How To Use Otezla?
Take the tablets by mouth every day, both in the morning and at night.
It can be taken with breakfast and dinner every day, or after brushing your teeth in the morning and at night. There is no need to crush, split, or chew the tablets. It can be taken with or without food.
A single pill is all you need on the first day.
There is one pill per day for people with severe kidney disease. It is important to follow your doctor's directions when taking Otezla.
It can take 12-16 weeks of proper use to experience the maximum benefit. Your symptoms may improve gradually over time during treatment.
What are the side effects of Otezla?
Check with your doctor immediately if any of the following side effects of Otezla occur:
- back pain
- runny or stuffy nose
- abdominal pain
- depression
- sinus headache
- insomnia
- bronchitis
- upper respiratory tract infection
- fatigue
- nausea
- indigestion/heartburn
- vomiting
- tooth abscess
- diarrhea, nausea and vomiting
- decreased appetite/weight loss
- headache
- diarrhea
Please consult your doctor for medical advice about side effects if you experience any. This is not a complete list of side effects, so you may experience others as well. Call your doctor if you find the side effects unmanageable.
Seek immediate medical attention if you experience trouble breathing, severe allergic reactions, suicidal thoughts or behaviours, or surprising changes in body weight.
What are Drug Interactions of Otezla?
Few known Drug Interactions of Otezla are listed below.
- folic acid
- meloxicam
- prednisone
- pantoprazole
- aspirin
- losartan
- Vitamin D3 (cholecalciferol)
- Vitamin B12 (cyanocobalamin)
- atorvastatin
- cyclobenzaprine
- omeprazole
- trazodone
- gabapentin
- metformin
- Cymbalta (duloxetine)
- methotrexate
- tramadol
- levothyroxine
- ibuprofen
- lisinopril
What is the recommended starting dose of Otezla?
The recommended starting dose of Otezla (apremilast) is 10 mg once daily on the first day, gradually increased over 5 days to reach the maintenance dose of 30 mg twice daily. This step-by-step increase helps reduce the risk of side effects like nausea and diarrhea.
Otezla cost in Canada?
Starting price of Otezla 30mg cost in Canada
- 56 tabs - $1419.50 USD ($25.35 per tab)
- 112 tabs - $2795.00 USD ($24.96 per tab)
Scroll up to see the specific pricing for each product, which is available in various strengths for both brand-name and generic options.
Generic Equivalent Apremilast cost in Canada?
Starting price of Apremilast 30mg cost in Canada
- 56 tabs -Â $1252.00 USD ($22.36 per tab)
- 112 tabs -Â $2482.00 USD ($22.16 per tab)
- 168 tabs -Â $3692.00 USD ($21.98 per tab)
Scroll up to see the specific pricing for each product, which is available in various strengths for both brand-name and generic options.
Otezla (Apremilast) FAQs
How long does it take for Otezla to start working?
Otezla usually starts working within 2 to 4 weeks, but it can take up to 16 weeks to see the full effects. The time varies depending on the condition being treated and how your body responds to the medication.
Is Otezla safe for children?
Otezla (apremilast) is approved for use in children ages 6 and older with certain conditions, such as moderate to severe plaque psoriasis. However, it’s important to use the medication under the guidance of a healthcare provider, as it may not be suitable for all children, and a doctor will need to assess the risks and benefits based on the child’s specific health needs.
Can Otezla cause allergic reactions?
Yes, Otezla can cause allergic reactions in some people. These reactions may include symptoms like skin rashes, itching, swelling, or difficulty breathing. If you experience any of these symptoms, you should seek medical help right away.
Do I need regular blood tests while taking Otezla?
No, you do not need regular blood tests while taking Otezla. However, your doctor may monitor you for any side effects or concerns during treatment. It's important to follow your doctor's advice and attend any recommended check-ups.
Can I crush or split Otezla tablets?
No, you should not crush or split Otezla tablets. It is important to take the tablets whole with or without food, as directed by your doctor. Crushing or splitting them can affect how the medication works. Always follow your doctor's instructions for taking Otezla.