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What is Otezla (apremilast) used for?

In the treatment of Behçet's disease, plaque psoriasis, and active psoriatic arthritis. The tablets are used twice a day to lower inflammation. During its action, apremilast inhibits an enzyme within your immune system that stimulates inflammation in your body and affects certain cells. This medicine belongs to the group of PDE4 inhibitors (Phosphodiesterase-4 Inhibitors). These lower inflammation by increasing our bodies' own messenger, cAMP (cyclic adenosine monophosphate).

Otezla FAQs

How To Use Otezla?

Take the tablets by mouth every day, both in the morning and at night.

It can be taken with breakfast and dinner every day, or after brushing your teeth in the morning and at night. There is no need to crush, split, or chew the tablets. It can be taken with or without food.

A single pill is all you need on the first day.

There is one pill per day for people with severe kidney disease. It is important to follow your doctor's directions when taking Otezla.

It can take 12-16 weeks of proper use to experience the maximum benefit. Your symptoms may improve gradually over time during treatment.

What are the side effects of Otezla?

Check with your doctor immediately if any of the following side effects of  Otezla occur:

  • back pain
  • runny or stuffy nose
  • abdominal pain
  • depression
  • sinus headache
  • insomnia
  • bronchitis
  • upper respiratory tract infection
  • fatigue
  • nausea
  • indigestion/heartburn
  • vomiting
  • tooth abscess
  • diarrhea, nausea and vomiting
  • decreased appetite/weight loss
  • headache
  • diarrhea

Please consult your doctor for medical advice about side effects if you experience any. This is not a complete list of side effects, so you may experience others as well. Call your doctor if you find the side effects unmanageable.

Seek immediate medical attention if you experience trouble breathing, severe allergic reactions, suicidal thoughts or behaviours, or surprising changes in body weight.

What are Drug Interactions of Otezla?

Few known Drug Interactions of Otezla are listed below.

  • folic acid
  • meloxicam
  • prednisone
  • pantoprazole
  • aspirin
  • losartan
  • Vitamin D3 (cholecalciferol)
  • Vitamin B12 (cyanocobalamin)
  • atorvastatin
  • cyclobenzaprine
  • omeprazole
  • trazodone
  • gabapentin
  • metformin
  • Cymbalta (duloxetine)
  • methotrexate
  • tramadol
  • levothyroxine
  • ibuprofen
  • lisinopril

How much does Otezla cost in Canada?

Starting price of Otezla 30 mg cost in Canada
- 56 tabs - $1350.00 USD ($24.11 per tabs)
- 112 tabs - $2660.00 USD ($23.75 per tabs)

Do you need a prescription for Otezla Solution in Canada?

You do require a prescription to order Otezla in Canada. Licensed pharmacies are unable to dispense prescription required drugs without one.

Disclaimer: The information contained in this page is to provide basic information on this product and is not intended to substitute medical advice from a licensed doctor. Always make sure to consult with a doctor before ordering medication online from Canada. Do not avoid or delay seeing a healthcare provider based on what you read here.